Antibiotic use after a typhoid conjugate vaccine: factors beyond vaccination in low-income countries

In conclusion, although vaccines have shown potential in reducing antimicrobial resistance, the study on Typbar-TCV in Harare did not find evidence of an effect on antibiotic prescribing. Factors such as unchanged clinical management, insufficient routine immunisation, and limited campaign scope could have contributed to this outcome. Addressing these challenges, such as diagnostics, socioeconomic support, and improved work environments are crucial for effective case management and optimal antibiotic use in low-income countries. Comprehensive approaches are needed to achieve lasting effects on antimicrobial resistance and patient care.